Preparation of Alginate Microspheres for the Delivery of Risperidone

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Published Dec 1, 2014
DOI https://doi.org/10.20428/yjms.v8i1.779

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Al-Tahami K.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Science and Technology, Sana’a, Yemen

Abstract

Aim: The aim of this research is to prepare and evaluate alginate microspheres of prolonged delivery of a model drug, Risperidone. Methods: Alginate microspheres containing Risperidone were prepared employing cross-linking method by calcium chloride. The formed microspheres were evaluated for percentage yield, drug content, drug loading, and encapsulation efficiency. In vitro release studies were carried out in phosphate buffer (pH 7.4). Results: The formed microspheres exhibited good drug loading and encapsulation efficiency. The drug release was sustained over a period of 8 hours. Conclusions: The fabricated Risperidone microspheres showed extended drug release, which could improve the therapeutic agent bioavailability and increase patient compliance. The delivery system developed can potentially serve for the delivery of many therapeutic agents.

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Keywords

Alginate, Microspheres, Sustained release, Risperidone

Issue
Vol. 8 No. 1 (2014)
Section
Original Article
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This work is licensed under a Creative Commons Attribution 4.0 International License.

YJMS publishes Open Access articles under the Creative Commons Attribution (CC BY) license. If author(s) submit their manuscript for consideration by YJMS, they agree to have the CC BY license applied to their work, which means that it may be reused in any form provided that the author(s) and the journal are properly cited. Under this license, author(s) also preserve the right of reusing the content of their manuscript provided that they cite the YJMS.

How to Cite
K., A.-T. (2014). Preparation of Alginate Microspheres for the Delivery of Risperidone. Yemeni Journal for Medical Sciences, 8(1), 19–23. https://doi.org/10.20428/yjms.v8i1.779