Comparative Efficacy of Magnesium Sulfate with versus without Local Anesthesia in Myofascial Pain Dysfunction Syndrome: A Prospective Study

الملخص

Background: Myofascial Pain Dysfunction Syndrome (MPDS) is a neuromuscular disorder characterized by myofascial trigger points—hyperirritable nodules within taut bands of skeletal muscle that cause localized or referred pain as well as autonomic symptoms.

Objective: This research aimed to evaluate magnesium sulfate's (MgSO₄) efficacy as a standalone treatment versus combination with conventional plain local anesthetic for myofascial pain dysfunction syndrome (MPDS). It also examined how demographic factors affected treatment results and compared them with the control group that had been administered standardized local anesthesia.

Method: A prospective study analysis is used for 40 patients (20 MPDS patients subdivided into MgSO₄ + anesthesia [n=10] and MgSO₄ monotherapy [n=10], alongside a control group [n=20]) assessed pain severity (Visual Analog Scale, VAS), functional recovery, and adverse events over a 9-month follow-up.

Results: Statistical analyses (ANOVA, chi-square) demonstrated that combined therapy resulted in complete symptom relief (VAS: 0/10) for all patients, matching the control group’s 100% pain-free outcomes (p>0.1). Conversely, MgSO₄ alone achieved only partial relief (50–60% VAS reduction), and 90% of the patients reported transient injection-site discomfort. Those aged 18–30 showed better recovery (100% versus 85% in older age groups, p=0.03), while quitting habits like 'chat' chewing was observed in faster improvement (p<0.01).

Conclusion: The study confirms that MgSO₄ combined with anesthesia performs as effectively as the control protocol, supporting tailored multimodal approaches: adjunctive anesthesia maximizes pain relief & function recovery. These findings highlight the role of age and lifestyle modifications in MPDS management, making combined therapy the optimal strategy for long-term clinical success.