Histopathological Profile of Colorectal Cancer in Yemen - An Eight Years Retrospective Study
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Abstract
Methods: This is a descriptive record-based study of 437 cases of CRC diagnosed by 2 pathologists, in the Department of pathology, Sana'a University, Yemen, during the period from 1st January 2005 to the 30th December 2012. The diagnosis was made on hematoxylin and eosin stained sections and categorized the cases of colon malignancies according to histological type.
Results: Out of 437 cases of CRC, 178 (40.7%) were females and 259 (59.3%) were males. The commonest type of CRC was adenocarcinoma comprising 404 cases (92.4%). The female cases were 167 (41.3%) whereas the male cases were 237 (58.7%). Non-Hodgkin's lymphomas (NHL) accounted, for 25 (5.7%). The rest of the cases were three carcinoid, two undifferentiated, two leiomyosarcomas, and one gastrointestinal malignant epithelioid tumor. The mean age, for adenocarcinoma in females was 53.5 years and 55 years in males. In NHL the mean age was 29.9 years in females and 28 years in males. The maximum number of patients 103 (27%) were found in 51-60 years age group and the minimum number of patients 35 (9.3%) were seen in over 70 years age group. Patients aged below 41 years demonstrated a high frequency 78 (20.6%). Well-differentiated adenocarcinomas accounted for 65.3% followed by mucinous carcinoma 11.4%, and moderately differentiated 10.1%. The poorly differentiated and the signet ring cell carcinomas accounted for 3.5% each. Two hundred twenty-seven (56.3%) cases were located in the recto-sigmoid area. The least number 15 (3.5%) was found in transverse colon.
Conclusion: The present series clearly illustrated a significant resemblance of our data with these from developing countries regarding the early age of onset and left side subsite preponderance and less aggressiveness behaviour of cancer.
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Colorectal cancer, adenocarcinoma, mucinous carcinoma, Yemen
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