Comparative Study Between Commercial Meloxicam Tablets in Yemen
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Abstract
Background: In low-income countries like Yemen, drug affordability plays a crucial role in medication selection, leading to increased reliance on generic alternatives to expensive branded drugs.
Objective: This study aimed to assess the quality control tests of three distinct meloxicam tablets, procured from pharmacies in Yemeni retail drug markets.
Method: This study was an experiment regarding the quality and physicochemical uniformity of three different meloxicam tablet products. All major factors were evaluated, including weight uniformity, tablet friability, crushing strength, disintegration, and dissolution tests.
Results: The findings indicated that all three products of Meloxicam 7.5 mg tablets were compatible with the standards of US Pharmacopoeia (USP) in terms of uniformity of weight (3.88–6.38), friability test (0.0885–0.2924), and disintegration time (1.30–5.30 min). The proportion of drug release for A, B and C brands was found to be 95.76%, 93.5%, and 94.32%, respectively, but in terms of the hardness test/crushing strength, all brands are within the limits (7.276 kg–4.52 kg), except B, which showed average hardness (2.31 kg). The following USP quality requirements were met by all the three different brands of Meloxicam 7.5 mg tablets, they passed both physical and chemical tests for friability and met the weight variation and disintegration and dissolution requirements.
Conclusion: The usage of affordable generic medications serves as a beneficial substitute option for innovator medications.
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meloxicam, quality control tests, Yemen, Market, friability, disintegration, dissolution
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