Gestational Trophoblastic Disease in Al-Thawra Hospital, Sana’a-Yemen

Abstract

Objective: To determine the incidence, types, complications, management and outcomes of gestational trophoblastic disease (GTD) in gynaecological and obstetric department in Al-Thawra Modern Hospital in Sana’a City during the period of one year.
Methodology: This is an observational descriptive study. All patients who diagnosed and registered as GTD during the period of the study (1st January to 31 of December 2011) were included in the study.
Results: During the study period, there were 13153 deliveries, 80 cases of them had gestational trophoblastic disease. The overall incidence of GTD was 1:164 deliveries. Forty women (50%) had partial mole, 35 women (43.75%) had complete mole, 3 women (3.75%) had choriocarcinoma and 2 women had invasive mole (2.5 %). With regard to methods of treatment 73cases (91.25%) Underwent suction evacuation, 5 cases (6.25%) underwent hysterectomy and 2 cases (2.5%) treated with hysterectomy. Of the 80 cases of GTD 9 cases (11.25%) developed persistent gestational trophoblast disease and received chemotherapy. Seven cases of them improved by receiving single agent chemotherapy (MTX), other two cases become resistant to (MTX), hysterectomy was done for both of them and received multi-agent chemotherapy, one of them improved and the other case not complete her follow up and came in advanced stage with lung and brain metastases then she died.
Conclusion: The study documented a hospital-based incidence of gestational trophoblast as 1:164. Partial hydatidiform mole was the most common type of GTD followed by complete hydatidiform mole chemotherapy is effective in treatment of persistent GTD.